Nature Communications (Feb 2016)

Liver-derived ketone bodies are necessary for food anticipation

  • Rohit Chavan,
  • Céline Feillet,
  • Sara S. Fonseca Costa,
  • James E. Delorme,
  • Takashi Okabe,
  • Jürgen A. Ripperger,
  • Urs Albrecht

DOI
https://doi.org/10.1038/ncomms10580
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Food anticipation is thought to be initiated by the central clock in the brain. Here the authors show that the peripheral organs initiate this process by showing that liver-specific deletion of Per2 can inhibit food anticipation by interfering with ß-hydroxybutyrate production and its subsequent processing in the brain.