Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis

Ai Kuzumi; Ayumi Yoshizaki; Kazuki M. Matsuda; Hirohito Kotani; Yuta Norimatsu; Maiko Fukayama; Satoshi Ebata; Takemichi Fukasawa; Asako Yoshizaki-Ogawa; Yoshihide Asano; Kyojiro Morikawa; Yutaka Kazoe; Kazuma Mawatari; Takehiko Kitamori; Shinichi Sato

doi:10.1038/s41467-021-26099-w

Nature Communications (Oct 2021)

Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis

Ai Kuzumi,
Ayumi Yoshizaki,
Kazuki M. Matsuda,
Hirohito Kotani,
Yuta Norimatsu,
Maiko Fukayama,
Satoshi Ebata,
Takemichi Fukasawa,
Asako Yoshizaki-Ogawa,
Yoshihide Asano,
Kyojiro Morikawa,
Yutaka Kazoe,
Kazuma Mawatari,
Takehiko Kitamori,
Shinichi Sato

Affiliations

Ai Kuzumi: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Ayumi Yoshizaki: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Kazuki M. Matsuda: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Hirohito Kotani: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Yuta Norimatsu: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Maiko Fukayama: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Satoshi Ebata: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Takemichi Fukasawa: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Asako Yoshizaki-Ogawa: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Yoshihide Asano: Department of Dermatology, Graduate School of Medicine, The University of Tokyo
Kyojiro Morikawa: Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo
Yutaka Kazoe: Department of System Design Engineering, Faculty of Science and Technology, Keio University
Kazuma Mawatari: Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo
Takehiko Kitamori: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
Shinichi Sato: Department of Dermatology, Graduate School of Medicine, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-021-26099-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Systemic sclerosis (SSc) disease involves multisystem fibrosis and autoimmunity with limited treatment options. Here the authors demonstrate that IL-31 and IL-31RA are overexpressed in dermal fibroblasts from SSc patients and show that fibrosis and cytokine release can be reduced upon blocking of IL-31/IL-31RA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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