Nature Communications (Mar 2017)
Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae
- Marie Trussart,
- Eva Yus,
- Sira Martinez,
- Davide Baù,
- Yuhei O. Tahara,
- Thomas Pengo,
- Michael Widjaja,
- Simon Kretschmer,
- Jim Swoger,
- Steven Djordjevic,
- Lynne Turnbull,
- Cynthia Whitchurch,
- Makoto Miyata,
- Marc A. Marti-Renom,
- Maria Lluch-Senar,
- Luís Serrano
Affiliations
- Marie Trussart
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Eva Yus
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Sira Martinez
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Davide Baù
- Gene Regulation, Stem Cells and Cancer Program. Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Yuhei O. Tahara
- Department of Biology, Graduate School of Science, Osaka City University
- Thomas Pengo
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Michael Widjaja
- The ithree Institute, The University of Technology Sydney, Sydney, New South Wales 2007, Australia
- Simon Kretschmer
- Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry
- Jim Swoger
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Steven Djordjevic
- The ithree Institute, The University of Technology Sydney, Sydney, New South Wales 2007, Australia
- Lynne Turnbull
- The ithree Institute, The University of Technology Sydney, Sydney, New South Wales 2007, Australia
- Cynthia Whitchurch
- The ithree Institute, The University of Technology Sydney, Sydney, New South Wales 2007, Australia
- Makoto Miyata
- Department of Biology, Graduate School of Science, Osaka City University
- Marc A. Marti-Renom
- Universitat Pompeu Fabra (UPF)
- Maria Lluch-Senar
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Luís Serrano
- EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- DOI
- https://doi.org/10.1038/ncomms14665
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The three-dimensional architecture of genome-reduced bacteria is poorly understood. Here the authors combine Hi-C with super-resolution microscopy inMycoplasma pneumoniaeand provide evidence of how supercoiling and local organization influences gene regulation.
