Nature Communications (Apr 2017)
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
- Paola A. Betancur,
- Brian J. Abraham,
- Ying Y. Yiu,
- Stephen B. Willingham,
- Farnaz Khameneh,
- Mark Zarnegar,
- Angera H. Kuo,
- Kelly McKenna,
- Yoko Kojima,
- Nicholas J. Leeper,
- Po Ho,
- Phung Gip,
- Tomek Swigut,
- Richard I. Sherwood,
- Michael F. Clarke,
- George Somlo,
- Richard A. Young,
- Irving L. Weissman
Affiliations
- Paola A. Betancur
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Brian J. Abraham
- Whitehead Institute for Biomedical Research
- Ying Y. Yiu
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Stephen B. Willingham
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Farnaz Khameneh
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Mark Zarnegar
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Angera H. Kuo
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Kelly McKenna
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Yoko Kojima
- Department of Surgery, Division of Vascular Surgery, Stanford University School of Medicine
- Nicholas J. Leeper
- Department of Surgery, Division of Vascular Surgery, Stanford University School of Medicine
- Po Ho
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Phung Gip
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Tomek Swigut
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- Richard I. Sherwood
- Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Michael F. Clarke
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- George Somlo
- Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center
- Richard A. Young
- Whitehead Institute for Biomedical Research
- Irving L. Weissman
- Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms14802
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance escape.
