Telomere maintenance: regulating hTERC fate through RNA modifications

Abstract

Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modifications may function in a regulated process serving to fine-tune the levels of hTERC.

Keywords

• smug1
• telomere
• rna processing
• hterc
• cancer
• base excision repair