Journal of Inflammation Research (Sep 2024)

Systemic Inflammatory Indicators and Risk of Incident Metabolically Unhealthy Phenotype

  • Zhao L,
  • Cui M,
  • Yang S,
  • Zhou H,
  • Li M

Journal volume & issue
Vol. Volume 17
pp. 6905 – 6916

Abstract

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Linlin Zhao,1,2 Man Cui,3 Saiqi Yang,1,2 Hui Zhou,1,2 Meng Li4 1Health Management Medicine Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Health Management Research Center, Central South University, Changsha, Hunan, People’s Republic of China; 3Department of Medical Administration, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 4Department of Endocrinology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Meng Li, Email [email protected]: This retrospective cohort study was designed to evaluate the association between eight systemic inflammation indicators at baseline and the metabolically unhealthy (MU) phenotype after two years of follow-up.Methods: Participants were defined as metabolically healthy (MH) if they met 0– 2 of the criteria and metabolically unhealthy (MU) if they met ≥ 3 of the criteria. A many of 4175 subjects aged 20– 80 years with a metabolically healthy (MH) phenotype at baseline were enrolled in the study. We compared the clinical characteristics between women and men enrolled at baseline according to the metabolic phenotype at follow-up. The associations between baseline inflammation indicators and MU status at follow-up were evaluated using logistic regression analysis.Results: 922 (22.08%) developed new-onset MU symptoms during follow-up. Logistic regression analysis found that most inflammation indicators were significantly associated with MU phenotype at follow-up, aside from the LMR and SII. After adjusting for potential confounders, only the correlations between CRP level, neutrophil count, and MU phenotype reached significance. In comparison to the control group with a CRP of 4.17 × 109 cells/L.Conclusion: CRP and neutrophil counts positively correlated with the risk of MU phenotype in Chinese subjects. These composite inflammatory markers (NLR, PLR, LMR, and SII) provide limited advantages for predicting MU risks compared to CRP.Keywords: systemic inflammation indicators, metabolically unhealthy phenotype, C-reactive protein, CRP

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