Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia

Heidi E. Lilja; Elina Suviolahti; Aino Soro-Paavonen; Tero Hiekkalinna; Aaron Day; Kenneth Lange; Eric Sobel; Marja-Riitta Taskinen; Leena Peltonen; Markus Perola; Päivi Pajukanta

Journal of Lipid Research (Oct 2004)

Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia

Heidi E. Lilja,
Elina Suviolahti,
Aino Soro-Paavonen,
Tero Hiekkalinna,
Aaron Day,
Kenneth Lange,
Eric Sobel,
Marja-Riitta Taskinen,
Leena Peltonen,
Markus Perola,
Päivi Pajukanta

Affiliations

Heidi E. Lilja: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Elina Suviolahti: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Aino Soro-Paavonen: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Tero Hiekkalinna: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Aaron Day: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Kenneth Lange: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Eric Sobel: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Marja-Riitta Taskinen: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Leena Peltonen: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Markus Perola: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Päivi Pajukanta: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; Department of Medical Genetics, University of Helsinki, Helsinki, Finland

Journal volume & issue: Vol. 45, no. 10
pp. 1876 – 1884

Abstract

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Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. This was supported by our previous pooled data analysis of the genome scans for low HDL-C and FCHL, which identified three shared chromosomal regions for a qualitative HDL-C trait on 8q23.1, 16q23.3, and 20q13.32. This study further investigates these regions as well as two other loci we identified earlier for premature CHD on 2q31 and Xq24 and a locus for high serum triglycerides (TGs) on 10q11. We analyzed 67 microsatellite markers in an extended study sample of 1,109 individuals from 92 low HDL-C or FCHL families using both qualitative and quantitative lipid phenotypes.These analyses provided evidence for linkage (a logarithm of odds score of 3.2) on 10q11 using a quantitative HDL-C trait. Importantly, this region, previously linked to TGs, body mass index, and obesity, provided evidence for association for quantitative TGs (P = 0.0006) and for a combined trait of HDL-C and TGs (P = 0.008) with marker D10S546. Suggestive evidence for linkage also emerged for HDL-C on 2q31 and for TGs on 20q13.32. Finnish families ascertained for dyslipidemias thus suggest that 10q11, 2q31, and 20q13.32 harbor loci for HDL-C and TGs.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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