Journal of International Medical Research (May 2021)

Development of a myelodysplastic/myeloproliferative neoplasm-unclassifiable in a patient with acute myeloid leukemia: a case report and literature review

  • Meifang Zhao,
  • Jingnan Sun,
  • Shanshan Liu,
  • Hongqiong Fan,
  • Yu Fu,
  • Yehui Tan,
  • Sujun Gao

DOI
https://doi.org/10.1177/03000605211018426
Journal volume & issue
Vol. 49

Abstract

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Myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are a heterogeneous group of hematologic malignancies characterized by dysplastic and myeloproliferative overlapping features in the bone marrow and blood. The occurrence of the disease is related to age, prior history of MPN or MDS, and recent cytotoxic or growth factor therapy, but it rarely develops after acute myeloid leukemia (AML). We report a rare case of a patient diagnosed with AML with t(8; 21)(q22; q22) who received systematic chemotherapy. After 4 years of follow-up, MDS/MPN-unclassifiable occurred without signs of primary AML recurrence.