Clinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine

Charlotte J. Neumann; Alexander Mahnert; Christina Kumpitsch; Raymond Kiu; Matthew J. Dalby; Magdalena Kujawska; Tobias Madl; Stefan Kurath-Koller; Berndt Urlesberger; Bernhard Resch; Lindsay J. Hall; Christine Moissl-Eichinger

doi:10.1038/s41467-023-36825-1

Nature Communications (Mar 2023)

Clinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine

Charlotte J. Neumann,
Alexander Mahnert,
Christina Kumpitsch,
Raymond Kiu,
Matthew J. Dalby,
Magdalena Kujawska,
Tobias Madl,
Stefan Kurath-Koller,
Berndt Urlesberger,
Bernhard Resch,
Lindsay J. Hall,
Christine Moissl-Eichinger

Affiliations

Charlotte J. Neumann: Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine; Medical University of Graz
Alexander Mahnert: Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine; Medical University of Graz
Christina Kumpitsch: Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine; Medical University of Graz
Raymond Kiu: Quadram Institute Bioscience, Norwich Research Park
Matthew J. Dalby: Quadram Institute Bioscience, Norwich Research Park
Magdalena Kujawska: Chair of Intestinal Microbiome, School of Life Sciences, ZIEL-Institute for Food & Health; Technical University of Munich
Tobias Madl: Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology & Biochemistry, Medical University of Graz
Stefan Kurath-Koller: Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz
Berndt Urlesberger: Division of Neonatology; Department of Paediatrics and Adolescent Medicine, Medical University of Graz
Bernhard Resch: Division of Neonatology; Department of Paediatrics and Adolescent Medicine, Medical University of Graz
Lindsay J. Hall: Quadram Institute Bioscience, Norwich Research Park
Christine Moissl-Eichinger: Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine; Medical University of Graz

DOI: https://doi.org/10.1038/s41467-023-36825-1
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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Here, the authors comparatively analyze the impact of three successful clinical preventive interventions against NEC in preterm, VLBW infants and demonstrate a major impact of especially probiotic-based strategies on the development and maturation of the gut microbiome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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