Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

Marina E. Emborg; Yan Liu; Jiajie Xi; Xiaoqing Zhang; Yingnan Yin; Jianfeng Lu; Valerie Joers; Christine Swanson; James E. Holden; Su-Chun Zhang

doi:10.1016/j.celrep.2013.02.016

Cell Reports (Mar 2013)

Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

Marina E. Emborg,
Yan Liu,
Jiajie Xi,
Xiaoqing Zhang,
Yingnan Yin,
Jianfeng Lu,
Valerie Joers,
Christine Swanson,
James E. Holden,
Su-Chun Zhang

Affiliations

Marina E. Emborg: Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Yan Liu: Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Jiajie Xi: Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Xiaoqing Zhang: Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Yingnan Yin: Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Jianfeng Lu: Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Valerie Joers: Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Christine Swanson: Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
James E. Holden: Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Su-Chun Zhang: Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA

DOI: https://doi.org/10.1016/j.celrep.2013.02.016
Journal volume & issue: Vol. 3, no. 3
pp. 646 – 650

Abstract

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The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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