Immune suppression in the early stage of COVID-19 disease

Wenmin Tian; Nan Zhang; Ronghua Jin; Yingmei Feng; Siyuan Wang; Shuaixin Gao; Ruqin Gao; Guizhen Wu; Di Tian; Wenjie Tan; Yang Chen; George Fu Gao; Catherine C. L. Wong

doi:10.1038/s41467-020-19706-9

Nature Communications (Nov 2020)

Immune suppression in the early stage of COVID-19 disease

Wenmin Tian,
Nan Zhang,
Ronghua Jin,
Yingmei Feng,
Siyuan Wang,
Shuaixin Gao,
Ruqin Gao,
Guizhen Wu,
Di Tian,
Wenjie Tan,
Yang Chen,
George Fu Gao,
Catherine C. L. Wong

Affiliations

Wenmin Tian: Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
Nan Zhang: Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
Ronghua Jin: Beijing Youan Hospital, Capital Medical University
Yingmei Feng: Beijing Youan Hospital, Capital Medical University
Siyuan Wang: Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
Shuaixin Gao: Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
Ruqin Gao: Qingdao Municipal Center for Disease Control and Prevention
Guizhen Wu: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)
Di Tian: Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University
Wenjie Tan: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)
Yang Chen: Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
George Fu Gao: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)
Catherine C. L. Wong: Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University

DOI: https://doi.org/10.1038/s41467-020-19706-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

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How COVID-19 pathology differs from other drivers of pneumonia is unclear. Here the authors analyze urine from patients with COVID-19 and identify an immunosuppressive protein expression pattern that is distinct from the pattern in healthy individuals or patients with non-COVID-19 pneumonia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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