A Sulfated Polysaccharide from Red Algae (<i>Gelidium crinale</i>) to Suppress Cells Metastasis and MMP-9 Expression of HT1080 Cells

Haiyan Zheng; Yu Pei; Yuan-Lin He; Yi Liu; Minqi Chen; Pengzhi Hong; Chunxia Zhou; Zhong-Ji Qian

doi:10.3390/foods11152360

Foods (Aug 2022)

A Sulfated Polysaccharide from Red Algae (<i>Gelidium crinale</i>) to Suppress Cells Metastasis and MMP-9 Expression of HT1080 Cells

Haiyan Zheng,
Yu Pei,
Yuan-Lin He,
Yi Liu,
Minqi Chen,
Pengzhi Hong,
Chunxia Zhou,
Zhong-Ji Qian

Affiliations

Haiyan Zheng: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Yu Pei: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Yuan-Lin He: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Yi Liu: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Minqi Chen: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Pengzhi Hong: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Chunxia Zhou: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China
Zhong-Ji Qian: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, School of Chemistry and Environment, College of Food Science and Technology, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Ocean University, Zhanjiang 524088, China

DOI: https://doi.org/10.3390/foods11152360
Journal volume & issue: Vol. 11, no. 15
p. 2360

Abstract

Read online

Sulfated polysaccharides from red algae have a variety of biological activities, especially antitumor activities. Matrix metalloproteinase-9 (MMP-9) is a proteolytic metalloenzyme that degrades the central part of the extracellular matrix (ECM) and promotes tumor metastasis. In this research, we have investigated the influence and mechanism of GNP (sulfated polysaccharide from Gelidium crinale) on tumor metastasis and MMP-9 expression of human fibrosarcoma (HT1080) cells. The results inflected that the concentration of GNP below 100 μg/mL has no toxicity to HT1080 cells, but showed excellent activity in inhibiting cells migration and invasion. In addition, GNP effectively inhibits the mRNA of MMP-9 and reduces its expression and activity by regulating nuclear factor-kappa B (NF-κB), mitogen-activated protein kinases (MAPK) and mTOR/PI3K/Akt signaling pathways. GNP has great potential as MMP-9 inhibitor and could be developed as a functional food or drug to prevent tumor metastasis.

Published in Foods

ISSN: 2304-8158 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology
Website: http://www.mdpi.com/journal/foods

About the journal

Abstract

Keywords