Personalized bioconversion of Panax notoginseng saponins mediated by gut microbiota between two different diet-pattern healthy subjects

Abstract

Highlights Panax notoginseng saponins could be biotransformed to generate five main metabolites, including GF1, GRh2, GC-K, PPT and PPD, by human gut microbiota. Gut microbiota profiles were significantly different in high protein, high fat and low fat, plant fiber-rich diet-pattern groups. Correlation analysis revealed potential relationships between metabolites and gut microbial species. Bifidobacterium adolescentis and Lactobacillus rhamnosus were selected as a representative species to metabolize PNS for the concerned metabolites.

Keywords

• Panax notoginseng saponins
• Gut microbiota
• 16S rRNA gene sequencing
• Metabolic variation
• Biotransformation