A case of eosinophilic bronchiolitis after the initiation of immune checkpoint inhibitor

Abstract

Abstract A 50‐year‐old Japanese woman with advanced breast cancer presented with productive cough and dyspnea while she was receiving a sixth cycle of chemotherapy including atezolizumab. Chest computed tomography revealed bronchiolitis and transbronchial lung cryobiopsy revealed eosinophilic bronchiolitis. Corticosteroid therapy successfully resolved her symptoms. Eosinophilic bronchiolitis is a rare but important immune‐related adverse event; herein, we discuss its diagnosis and possible pathophysiology.

Keywords

• atezolizumab
• bronchiolitis
• eosinophil
• immune checkpoint inhibitor
• immune‐related adverse event