Deoxyribonucleic Acid 5-Hydroxymethylation in Cell-Free Deoxyribonucleic Acid, a Novel Cancer Biomarker in the Era of Precision Medicine

Ling Xu; Ling Xu; Yixin Zhou; Lijie Chen; Abdul Saad Bissessur; Abdul Saad Bissessur; Jida Chen; Misha Mao; Misha Mao; Siwei Ju; Siwei Ju; Lini Chen; Lini Chen; Cong Chen; Cong Chen; Zhaoqin Li; Zhaoqin Li; Xun Zhang; Xun Zhang; Fei Chen; Fei Chen; Feilin Cao; Linbo Wang; Qinchuan Wang

doi:10.3389/fcell.2021.744990

Frontiers in Cell and Developmental Biology (Dec 2021)

Deoxyribonucleic Acid 5-Hydroxymethylation in Cell-Free Deoxyribonucleic Acid, a Novel Cancer Biomarker in the Era of Precision Medicine

Ling Xu,
Ling Xu,
Yixin Zhou,
Lijie Chen,
Abdul Saad Bissessur,
Abdul Saad Bissessur,
Jida Chen,
Misha Mao,
Misha Mao,
Siwei Ju,
Siwei Ju,
Lini Chen,
Lini Chen,
Cong Chen,
Cong Chen,
Zhaoqin Li,
Zhaoqin Li,
Xun Zhang,
Xun Zhang,
Fei Chen,
Fei Chen,
Feilin Cao,
Linbo Wang,
Qinchuan Wang

Affiliations

Ling Xu: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Ling Xu: School of Medicine, Zhejiang University, Hangzhou, China
Yixin Zhou: Department of Thyroid and Breast Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Luqiao, China
Lijie Chen: Department of Thyroid and Breast Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Luqiao, China
Abdul Saad Bissessur: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Abdul Saad Bissessur: School of Medicine, Zhejiang University, Hangzhou, China
Jida Chen: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Misha Mao: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Misha Mao: School of Medicine, Zhejiang University, Hangzhou, China
Siwei Ju: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Siwei Ju: School of Medicine, Zhejiang University, Hangzhou, China
Lini Chen: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Lini Chen: School of Medicine, Zhejiang University, Hangzhou, China
Cong Chen: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Cong Chen: School of Medicine, Zhejiang University, Hangzhou, China
Zhaoqin Li: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Zhaoqin Li: School of Medicine, Zhejiang University, Hangzhou, China
Xun Zhang: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Xun Zhang: School of Medicine, Zhejiang University, Hangzhou, China
Fei Chen: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Fei Chen: School of Medicine, Zhejiang University, Hangzhou, China
Feilin Cao: Department of Thyroid and Breast Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Luqiao, China
Linbo Wang: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Qinchuan Wang: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.3389/fcell.2021.744990
Journal volume & issue: Vol. 9

Abstract

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Aberrant methylation has been regarded as a hallmark of cancer. 5-hydroxymethylcytosine (5hmC) is recently identified as the ten-eleven translocase (ten-eleven translocase)-mediated oxidized form of 5-methylcytosine, which plays a substantial role in DNA demethylation. Cell-free DNA has been introduced as a promising tool in the liquid biopsy of cancer. There are increasing evidence indicating that 5hmC in cell-free DNA play an active role during carcinogenesis. However, it remains unclear whether 5hmC could surpass classical markers in cancer detection, treatment, and prognosis. Here, we systematically reviewed the recent advances in the clinic and basic research of DNA 5-hydroxymethylation in cancer, especially in cell-free DNA. We further discuss the mechanisms underlying aberrant 5hmC patterns and carcinogenesis. Synergistically, 5-hydroxymethylation may act as a promising biomarker, unleashing great potential in early cancer detection, prognosis, and therapeutic strategies in precision oncology.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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