Is There A Decline in Inflammatory Markers with Weight Loss in Obese Women? Obesity Outpatient Clinic Six-Month Follow-Up Results

Abstract

INTRODUCTION: The aim of our study is to determine the change in the neutrophil / lymphocyte ratio (NLR), which is an inflammatory marker of obesity in patients who lose weight with lifestyle changes. METHODS: Our study was conducted with 74 obese female patients who significantly lost weight with six-month lifestyle changes in the obesity outpatient clinic. Patients with acute or chronic inflammatory disease and diabetes were excluded from the study. Clinical data, anthropometric measurements and laboratory results were collected from the patients' files retrospectively. RESULTS: The mean age of the patients was 49.24+-9.89 years. Weight and BMI values of the patients at the beginning of the study were 95.44 +-15.60 kg and 37.75+-5.74 kg/m² and at the end of the sixth month 87.99+-15.70 kg and 34.78+-5.78 kg / m² respectively. The fasting plasma insulin, C peptide levels and HOMA of the patients the beginning and at the sixth month of the study were 12.96 uU/ml and 9.19 uU/ml (p = 0.015) and 2.74 ng/ml to 2.29 ng/ml and 3.31 to 2.03 respectively (p = 0.021). The NLR values of the patients who lost weight decreased significantly compared to baseline values (p = 0.004). There was no significant difference between baseline and sixth month CRP values (p = 0.586). DISCUSSION AND CONCLUSION: As a result, it was found that there was a significant decrease in NLR value together with a decrease in insulin resistance when weight loss was achieved with lifestyle changes in obese women.

Keywords

• obesity
• life style manegement
• weight loss
• inflammation
• neutrophil lymphpcyte ratio