Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

Akinobu Senoo; Sho Ito; Satoru Nagatoishi; Yutaro Saito; Go Ueno; Daisuke Kuroda; Kouhei Yoshida; Takumi Tashima; Shota Kudo; Shinsuke Sando; Kouhei Tsumoto

doi:10.1038/s42003-021-02575-3

Communications Biology (Sep 2021)

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

Akinobu Senoo,
Sho Ito,
Satoru Nagatoishi,
Yutaro Saito,
Go Ueno,
Daisuke Kuroda,
Kouhei Yoshida,
Takumi Tashima,
Shota Kudo,
Shinsuke Sando,
Kouhei Tsumoto

Affiliations

Akinobu Senoo: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Sho Ito: Graduate School of Life Science, University of Hyogo
Satoru Nagatoishi: Institute of Medical Science, The University of Tokyo
Yutaro Saito: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Go Ueno: RIKEN SPring-8 Center
Daisuke Kuroda: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Kouhei Yoshida: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
Takumi Tashima: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Shota Kudo: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Shinsuke Sando: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Kouhei Tsumoto: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo

DOI: https://doi.org/10.1038/s42003-021-02575-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Senoo et al. describe a chemical fragment that disrupts dimerization of P-cadherin. In doing so, this fragment inhibits cadherin-mediated cell-adhesion and aggregation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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