Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Nicholas C. Wu; Jakub Otwinowski; Andrew J. Thompson; Corwin M. Nycholat; Armita Nourmohammad; Ian A. Wilson

doi:10.1038/s41467-020-15102-5

Nature Communications (Mar 2020)

Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Nicholas C. Wu,
Jakub Otwinowski,
Andrew J. Thompson,
Corwin M. Nycholat,
Armita Nourmohammad,
Ian A. Wilson

Affiliations

Nicholas C. Wu: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Jakub Otwinowski: Max Planck Institute for Dynamics and Self-Organization
Andrew J. Thompson: Department of Molecular Medicine, The Scripps Research Institute
Corwin M. Nycholat: Department of Molecular Medicine, The Scripps Research Institute
Armita Nourmohammad: Max Planck Institute for Dynamics and Self-Organization
Ian A. Wilson: Department of Integrative Structural and Computational Biology, The Scripps Research Institute

DOI: https://doi.org/10.1038/s41467-020-15102-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providing insights into evolvability of influenza antigenicity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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