Catalysts (Sep 2021)
Synthesis of 2-Methylquinoxaline Derivatives from Glycerol and Diamines Catalyzed by Iridium Complexes Bearing an <i>N</i>-Heterocyclic Carbene Ligand
Abstract
2-Methylquinoxaline derivatives are widely used as intermediates in the synthesis of pharmaceuticals, natural products, and dyes; however, their syntheses usually require excess reagents, making them environmentally burdensome. Meanwhile, glycerol can be sustainably obtained in large quantities as a by-product in the production of biodiesel fuel using waste oil as a raw material. Thus, it is worthwhile to develop a new catalytic system that utilizes glycerol as a C3 source. In this study, an efficient catalytic system was developed to obtain 2-methylquinoxaline derivatives from glycerol and 1,2-phenylenediamines. This system is beneficial because it is environmentally friendly and has excellent atom efficiency.
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