NATURAL COVALENTLY COMBINED DERIVATIVES OF 2H-1-BENZOPYRAN-2-ONE

Abstract

Coumarins, known as 2Н-1-benzopyran-2-one (or 2H-chromen-2-one), are present in remarkable amounts in plants, also have been detected in microorganisms and animal sources. The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of polycyclic coumarins, which possess extremely important pharmacological activity. This paper presents the results of a full analysis of domestic and foreign literature in the field of research on the combined covalent derivatives 2H-1-benzopyran-2-one of natural origin. It is shown that at the present time, researchers are paying extraordinary attention to this class of compounds, based on the many points of view and actively expand the area of their practical application, especially in the prevention and treatment of diseases of the cardiovascular and immune systems.

Keywords

• coumarins
• combined natural coumarins
• drugs
• «structure - activity» relationship