Química Nova (Jan 2008)
Síntese de 1-indanonas através da reação de acilação de Friedel-Crafts intramolecular utilizando NbCl5 como ácido de Lewis Synthesis of 1-indanones through the intramolecular Friedel-Crafts acylation reaction using NbCl5 as Lewis acid
Abstract
The intramolecular Friedel-Crafts acylation reaction of 3-arylpropanoic acids to give 1-indanones can be effected in good yields under mild conditions (room temperature) by using niobium pentachloride. Our results indicate that NbCl5 acts both as reagent (to transform carboxylic acids into acyl chlorides) and as catalyst in the Friedel-Crafts cyclization.
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