The RNA landscape of the human placenta in health and disease

Sungsam Gong; Francesca Gaccioli; Justyna Dopierala; Ulla Sovio; Emma Cook; Pieter-Jan Volders; Lennart Martens; Paul D. W. Kirk; Sylvia Richardson; Gordon C. S. Smith; D. Stephen Charnock-Jones

doi:10.1038/s41467-021-22695-y

Nature Communications (May 2021)

The RNA landscape of the human placenta in health and disease

Sungsam Gong,
Francesca Gaccioli,
Justyna Dopierala,
Ulla Sovio,
Emma Cook,
Pieter-Jan Volders,
Lennart Martens,
Paul D. W. Kirk,
Sylvia Richardson,
Gordon C. S. Smith,
D. Stephen Charnock-Jones

Affiliations

Sungsam Gong: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Francesca Gaccioli: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Justyna Dopierala: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Ulla Sovio: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Emma Cook: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
Pieter-Jan Volders: Computational Omics and Systems Biology Group, Department of Biochemistry, Ghent University
Lennart Martens: Computational Omics and Systems Biology Group, Department of Biochemistry, Ghent University
Paul D. W. Kirk: MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge
Sylvia Richardson: MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge
Gordon C. S. Smith: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre
D. Stephen Charnock-Jones: Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre

DOI: https://doi.org/10.1038/s41467-021-22695-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Placental dysfunction can have catastrophic or barely discernible effects ranging from miscarriage to apparently normal birth. Here the authors present a comprehensive analysis of the human placental transcriptome and identify circular RNAs and piRNAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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