Nature Communications (Aug 2018)
Genomic patterns of progression in smoldering multiple myeloma
- Niccolò Bolli,
- Francesco Maura,
- Stephane Minvielle,
- Dominik Gloznik,
- Raphael Szalat,
- Anthony Fullam,
- Inigo Martincorena,
- Kevin J. Dawson,
- Mehmet Kemal Samur,
- Jorge Zamora,
- Patrick Tarpey,
- Helen Davies,
- Mariateresa Fulciniti,
- Masood A. Shammas,
- Yu Tzu Tai,
- Florence Magrangeas,
- Philippe Moreau,
- Paolo Corradini,
- Kenneth Anderson,
- Ludmil Alexandrov,
- David C. Wedge,
- Herve Avet-Loiseau,
- Peter Campbell,
- Nikhil Munshi
Affiliations
- Niccolò Bolli
- Department of Oncology and Hemato-Oncology, University of Milan
- Francesco Maura
- Department of Oncology and Hemato-Oncology, University of Milan
- Stephane Minvielle
- CRCINA, INSERM, CNRS, Université de Nantes, Université d’Angers
- Dominik Gloznik
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Raphael Szalat
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Anthony Fullam
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Inigo Martincorena
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Kevin J. Dawson
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Mehmet Kemal Samur
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Jorge Zamora
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Patrick Tarpey
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Helen Davies
- Cancer Genome Project, Wellcome Trust Sanger Institute
- Mariateresa Fulciniti
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Masood A. Shammas
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Yu Tzu Tai
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Florence Magrangeas
- CRCINA, INSERM, CNRS, Université de Nantes, Université d’Angers
- Philippe Moreau
- CRCINA, INSERM, CNRS, Université de Nantes, Université d’Angers
- Paolo Corradini
- Department of Oncology and Hemato-Oncology, University of Milan
- Kenneth Anderson
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Ludmil Alexandrov
- Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego
- David C. Wedge
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Herve Avet-Loiseau
- Genomics of Myeloma Laboratory, L’Institut Universitaire du Cancer Oncopole
- Peter Campbell
- Department of Oncology and Hemato-Oncology, University of Milan
- Nikhil Munshi
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-018-05058-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Smoldering MM (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM progressing to MM, and show that the genomic landscape at the SMM stage is very similar to MM, but trajectories of evolution can vary from patient to patient.
