Nature Communications (Dec 2019)
Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
- L. D’Abate,
- S. Walker,
- R. K. C. Yuen,
- K. Tammimies,
- J. A. Buchanan,
- R. W. Davies,
- B. Thiruvahindrapuram,
- J. Wei,
- J. Brian,
- S. E. Bryson,
- K. Dobkins,
- J. Howe,
- R. Landa,
- J. Leef,
- D. Messinger,
- S. Ozonoff,
- I. M. Smith,
- W. L. Stone,
- Z. E. Warren,
- G. Young,
- L. Zwaigenbaum,
- S. W. Scherer
Affiliations
- L. D’Abate
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- S. Walker
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- R. K. C. Yuen
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- K. Tammimies
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- J. A. Buchanan
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- R. W. Davies
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- B. Thiruvahindrapuram
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- J. Wei
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- J. Brian
- Autism Research Centre, Bloorview Research Institute and University of Toronto
- S. E. Bryson
- Autism Research Centre, IWK Health Centre and Dalhousie University
- K. Dobkins
- Department of Psychology, UC San Diego
- J. Howe
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- R. Landa
- Center for Autism and Related Disorders, Kennedy Krieger Institute
- J. Leef
- Autism Research Centre, Bloorview Research Institute and University of Toronto
- D. Messinger
- Department of Psychology, University of Miami
- S. Ozonoff
- MIND Institute, Department of Psychiatry, UC Davis
- I. M. Smith
- Autism Research Centre, IWK Health Centre and Dalhousie University
- W. L. Stone
- Department of Psychology, University of Washington
- Z. E. Warren
- Vanderbilt Kennedy Center Treatment and Research Institute for Autism Spectrum Disorders, Vanderbilt Kennedy Centre
- G. Young
- MIND Institute, Department of Psychiatry, UC Davis
- L. Zwaigenbaum
- Autism Research Centre, University of Alberta
- S. W. Scherer
- The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-019-13380-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Siblings of those with autism spectrum disorder (ASD) have increased likelihood of ASD or related subclinical traits. Here, studying 253 ASD families, D’Abate et al. test the predictive value of genomic copy number variation involving ASD-associated loci, with confirmation in a second cohort.
