Nature Communications (Jun 2021)

Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment

  • Yuechen Luo,
  • Changlu Xu,
  • Bing Wang,
  • Qing Niu,
  • Xiuhua Su,
  • Yingnan Bai,
  • Shuxian Zhu,
  • Chunxiao Zhao,
  • Yunyan Sun,
  • Jiali Wang,
  • Maolan Liu,
  • Xiaolei Sun,
  • Ge Song,
  • Haidong Cui,
  • Xiaoli Chen,
  • Huifang Huang,
  • Haikun Wang,
  • Mingzhe Han,
  • Erlie Jiang,
  • Lihong Shi,
  • Xiaoming Feng

DOI
https://doi.org/10.1038/s41467-021-24213-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Human Treg cells are central to immune tolerance, yet their heterogeneity and differentiation remain incompletely understood. Here the authors perform single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host disease revealing Treg complexity in health and disease.