Research progress on STAT3 and pathogenesis of Parkinson's disease

Abstract

Parkinson's disease (PD) is a chronic progressive neurodegenerative disease. Signal transducer and activator of transcription 3 (STAT3) is involved in the development and progression of PD, oxidative stress, neuro-inflammatory response, abnormal α-synuclein aggregation, mitochondrial dysfunction and iron death, so they are expected to be a new therapeutic targets and provide new research ideas for the treatment of PD.

Keywords

• stat3 transcription factor|parkinson's disease|pathogenesis