Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes

Chenchen Zhu; Jingyan Wu; Han Sun; Francesca Briganti; Benjamin Meder; Wu Wei; Lars M. Steinmetz

doi:10.1038/s41467-021-24484-z

Nature Communications (Jul 2021)

Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes

Chenchen Zhu,
Jingyan Wu,
Han Sun,
Francesca Briganti,
Benjamin Meder,
Wu Wei,
Lars M. Steinmetz

Affiliations

Chenchen Zhu: Department of Genetics, School of Medicine, Stanford University
Jingyan Wu: Department of Genetics, School of Medicine, Stanford University
Han Sun: Department of Genetics, School of Medicine, Stanford University
Francesca Briganti: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Benjamin Meder: Department of Genetics, School of Medicine, Stanford University
Wu Wei: CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Lars M. Steinmetz: Department of Genetics, School of Medicine, Stanford University

DOI: https://doi.org/10.1038/s41467-021-24484-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Alternative splicing generates RNA isoforms that contribute to phenotypic diversity. Here the authors perform single-molecule full-length RNA sequencing to identify disease-associated variant transcript isoforms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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