Nature Communications (Jun 2019)
Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
- Rajkumar Dorajoo,
- Xuling Chang,
- Resham Lal Gurung,
- Zheng Li,
- Ling Wang,
- Renwei Wang,
- Kenneth B. Beckman,
- Jennifer Adams-Haduch,
- Yiamunaa M,
- Sylvia Liu,
- Wee Yang Meah,
- Kar Seng Sim,
- Su Chi Lim,
- Yechiel Friedlander,
- Jianjun Liu,
- Rob M. van Dam,
- Jian-Min Yuan,
- Woon-Puay Koh,
- Chiea Chuen Khor,
- Chew-Kiat Heng
Affiliations
- Rajkumar Dorajoo
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Xuling Chang
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Resham Lal Gurung
- Clinical Research Unit, Khoo Teck Puat Hospital
- Zheng Li
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Ling Wang
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Renwei Wang
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Kenneth B. Beckman
- University of Minnesota Genomics Center, University of Minnesota
- Jennifer Adams-Haduch
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Yiamunaa M
- Clinical Research Unit, Khoo Teck Puat Hospital
- Sylvia Liu
- Clinical Research Unit, Khoo Teck Puat Hospital
- Wee Yang Meah
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Kar Seng Sim
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Su Chi Lim
- Clinical Research Unit, Khoo Teck Puat Hospital
- Yechiel Friedlander
- School of Public Health and Community Medicine, Hebrew University of Jerusalem
- Jianjun Liu
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Rob M. van Dam
- Saw Swee Hock School of Public Health, National University of Singapore
- Jian-Min Yuan
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Woon-Puay Koh
- Saw Swee Hock School of Public Health, National University of Singapore
- Chiea Chuen Khor
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Chew-Kiat Heng
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-019-10443-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Shortening of leukocyte telomere length (LTL) is associated with age and increased risk for various chronic diseases. Here, the authors report genome-wide association studies for LTL in Singaporean Chinese populations and find that longer LTL associates with less severe outcomes of respiratory disease phenotypes.
