Communications Biology (Sep 2022)
Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
- Zhicheng Hu,
- Pradeep Kumar Kopparapu,
- Patrick Ebner,
- Majd Mohammad,
- Simon Lind,
- Anders Jarneborn,
- Claes Dahlgren,
- Michelle Schultz,
- Meghshree Deshmukh,
- Rille Pullerits,
- Mulugeta Nega,
- Minh-Thu Nguyen,
- Ying Fei,
- Huamei Forsman,
- Friedrich Götz,
- Tao Jin
Affiliations
- Zhicheng Hu
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Pradeep Kumar Kopparapu
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Patrick Ebner
- Department of Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
- Majd Mohammad
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Simon Lind
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Anders Jarneborn
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Claes Dahlgren
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Michelle Schultz
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Meghshree Deshmukh
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Rille Pullerits
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Mulugeta Nega
- Department of Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
- Minh-Thu Nguyen
- Institute of Medical Microbiology, University Hospital of Münster
- Ying Fei
- Center for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University
- Huamei Forsman
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Friedrich Götz
- Department of Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen
- Tao Jin
- Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- DOI
- https://doi.org/10.1038/s42003-022-03839-2
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
Phenol-soluble modulin α and β display divergent roles in staphylococcal infection and its associated septic arthritis - whereas PSMα is a virulence factor for neutrophils that worsens infection, PSMβ protects from the development of septic arthritis.
