Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Hyojin Kim; Yaoyao Fu; Ho Jeong Hong; Seong-Gyu Lee; Dong Sun Lee; Ho Min Kim

doi:10.1038/s41467-022-32214-2

Nature Communications (Jul 2022)

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Hyojin Kim,
Yaoyao Fu,
Ho Jeong Hong,
Seong-Gyu Lee,
Dong Sun Lee,
Ho Min Kim

Affiliations

Hyojin Kim: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Yaoyao Fu: Center for Biomolecular & Cellular Structure, IBS
Ho Jeong Hong: Center for Biomolecular & Cellular Structure, IBS
Seong-Gyu Lee: Center for Biomolecular & Cellular Structure, IBS
Dong Sun Lee: Center for Biomolecular & Cellular Structure, IBS
Ho Min Kim: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s41467-022-32214-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Insulin-like growth factor 1 (IGF1) regulates growth and differentiation. Here, authors report the atomic structure of the ternary complex (IGF1/IGF-binding protein3/acid labile subunit) and its assembly/disassembly mechanism for IGF bioavailability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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