The role of regional and neuroaxial anesthesia in patients with systemic sclerosis

Abstract

Zoey Sarah Dempsey1, Simone Rowell2, Rose McRobert31Department of Anaesthesia, Southern General Hospital, Glasgow, Lanarkshire, 2Department of Anaesthesia, Western Infirmary, Glasgow, Lanarkshire, 3Department of Anaesthesia, The Ayr Hospital, Ayr, Aryshire, UKAbstract: Systemic sclerosis (SSc), previously known as progressive systemic sclerosis, is a form of scleroderma and a multisystem connective tissue disease which can impact on every aspect of anesthetic care, especially airway management. In this review we outline clinical manifestations and current medical treatment of the disease, and general principles of anesthetizing these patients. We focus on the role of regional anesthesia, including neuroaxial anesthesia, which may serve as a safe alternative to general anesthesia but can be technically challenging. We address concerns regarding abnormal responses to local anesthesia which have previously been reported in patients with SSc, and explore future developments in technology and pharmacology, which may enable regional anesthesia to be performed more successfully and with fewer complications.Keywords: systemic sclerosis, scleroderma, regional anesthesia, neuroaxial anesthesia