CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking

Szu-Yi Chou; Kuo-Shun Hsu; Wataru Otsu; Ya-Chu Hsu; Yun-Cin Luo; Celine Yeh; Syed S. Shehab; Jie Chen; Vincent Shieh; Guo-an He; Michael B. Marean; Diane Felsen; Aihao Ding; Dix P. Poppas; Jen-Zen Chuang; Ching-Hwa Sung

doi:10.1038/ncomms10412

Nature Communications (Jan 2016)

CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking

Szu-Yi Chou,
Kuo-Shun Hsu,
Wataru Otsu,
Ya-Chu Hsu,
Yun-Cin Luo,
Celine Yeh,
Syed S. Shehab,
Jie Chen,
Vincent Shieh,
Guo-an He,
Michael B. Marean,
Diane Felsen,
Aihao Ding,
Dix P. Poppas,
Jen-Zen Chuang,
Ching-Hwa Sung

Affiliations

Szu-Yi Chou: Department of Ophthalmology, Weill Cornell Medical College
Kuo-Shun Hsu: Department of Ophthalmology, Weill Cornell Medical College
Wataru Otsu: Department of Ophthalmology, Weill Cornell Medical College
Ya-Chu Hsu: Department of Ophthalmology, Weill Cornell Medical College
Yun-Cin Luo: Department of Ophthalmology, Weill Cornell Medical College
Celine Yeh: Department of Ophthalmology, Weill Cornell Medical College
Syed S. Shehab: Department of Urology, Institute for Pediatric Urology, Weill Cornell Medical College
Jie Chen: Department of Urology, Institute for Pediatric Urology, Weill Cornell Medical College
Vincent Shieh: Department of Ophthalmology, Weill Cornell Medical College
Guo-an He: Department of Microbiology and Immunology, Weill Cornell Medical College
Michael B. Marean: Department of Urology, Institute for Pediatric Urology, Weill Cornell Medical College
Diane Felsen: Department of Urology, Institute for Pediatric Urology, Weill Cornell Medical College
Aihao Ding: Department of Microbiology and Immunology, Weill Cornell Medical College
Dix P. Poppas: Department of Urology, Institute for Pediatric Urology, Weill Cornell Medical College
Jen-Zen Chuang: Department of Ophthalmology, Weill Cornell Medical College
Ching-Hwa Sung: Department of Ophthalmology, Weill Cornell Medical College

DOI: https://doi.org/10.1038/ncomms10412
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Chloride intracellular channel (CLIC) 4 is an ion channel, localized in the cytoplasm, and first identified as an actin binding protein. Here, Chou et al.knockout CLIC4 in mice and observe tubulogenesis and renal proximal tubule dilation defects, which is caused by irregular actin and endosomal trafficking.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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