Nature Communications (Jul 2022)
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice
- Liang Yong,
- Yafen Yu,
- Bao Li,
- Huiyao Ge,
- Qi Zhen,
- Yiwen Mao,
- Yanxia Yu,
- Lu Cao,
- Ruixue Zhang,
- Zhuo Li,
- Yirui Wang,
- Wencheng Fan,
- Chang Zhang,
- Daiyue Wang,
- Sihan Luo,
- Yuanming Bai,
- Shirui Chen,
- Weiwei Chen,
- Miao Liu,
- Jijia Shen,
- Liangdan Sun
Affiliations
- Liang Yong
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Yafen Yu
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Bao Li
- Integrated Laboratory, School of Basic Medical Sciences, Anhui Medical University
- Huiyao Ge
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Qi Zhen
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Yiwen Mao
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Yanxia Yu
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Lu Cao
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Ruixue Zhang
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Zhuo Li
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Yirui Wang
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Wencheng Fan
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Chang Zhang
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Daiyue Wang
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Sihan Luo
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Yuanming Bai
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Shirui Chen
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Weiwei Chen
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- Miao Liu
- Anhui Provincial Laboratory of Microbiology and Parasitology; Department of Microbiology and Parasitology, Anhui Medical University
- Jijia Shen
- Anhui Provincial Laboratory of Microbiology and Parasitology; Department of Microbiology and Parasitology, Anhui Medical University
- Liangdan Sun
- Department of Dermatology, the First Affiliated Hospital of Anhui Medical University
- DOI
- https://doi.org/10.1038/s41467-022-31935-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Calcium/calmodulin-dependent protein kinase IV (CaMK4) has been shown to be involved in autoimmunity but it is not clear how it functions in psoriasis. Here the authors show that CaMK4 is increased in psoriasis and promotes inflammatory responses in mouse models of psoriasis mediated through macrophages and keratinocytes.
