ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development

Nadjet Gacem; Anthula Kavo; Lisa Zerad; Laurence Richard; Stephane Mathis; Raj P. Kapur; Melanie Parisot; Jeanne Amiel; Sylvie Dufour; Pierre de la Grange; Veronique Pingault; Jean Michel Vallat; Nadege Bondurand

doi:10.1038/s41467-019-14090-5

Nature Communications (Jan 2020)

ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development

Nadjet Gacem,
Anthula Kavo,
Lisa Zerad,
Laurence Richard,
Stephane Mathis,
Raj P. Kapur,
Melanie Parisot,
Jeanne Amiel,
Sylvie Dufour,
Pierre de la Grange,
Veronique Pingault,
Jean Michel Vallat,
Nadege Bondurand

Affiliations

Nadjet Gacem: Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR 1163, Universite Paris Descartes—Universite de Paris
Anthula Kavo: INSERM, U955, Equipe 06
Lisa Zerad: Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR 1163, Universite Paris Descartes—Universite de Paris
Laurence Richard: Department of Neurology, Centre de Reference Neuropathies Peripheriques Rares
Stephane Mathis: Department of Neurology (Nerve-Muscle Unit) and Grand Sud-Ouest National Reference Center for Neuromuscular Disorders, CHU Bordeaux, Pellegrin Hospital
Raj P. Kapur: Department of Pathology, Seattle Children’s Hospital and University of Washington
Melanie Parisot: Genomics Core Facility, Institut Imagine-Structure Federative de Recherche Necker, INSERM U1163 and INSERM US24/CNRS UMS3633
Jeanne Amiel: Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR 1163, Universite Paris Descartes—Universite de Paris
Sylvie Dufour: INSERM, U955, Equipe 06
Pierre de la Grange: GenoSplice
Veronique Pingault: Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR 1163, Universite Paris Descartes—Universite de Paris
Jean Michel Vallat: Department of Neurology, Centre de Reference Neuropathies Peripheriques Rares
Nadege Bondurand: Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR 1163, Universite Paris Descartes—Universite de Paris

DOI: https://doi.org/10.1038/s41467-019-14090-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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ADAR1 is an RNA editing protein known to regulate immune responses to dsRNA that has been connected to neural crest cell function. Here, the authors show RNA editing by ADAR1 is important for the normal development of neural crest derived melanocytes and Schwann cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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