APL Materials (Jun 2024)

Light-induced antimicrobial activities of porphyrin derivatives as photosensitizers

  • Shengman Yu,
  • Jingwei Shi,
  • Tingting Sun,
  • Zhigang Xie,
  • Liyuan Sun

DOI
https://doi.org/10.1063/5.0213923
Journal volume & issue
Vol. 12, no. 6
pp. 061110 – 061110-7

Abstract

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Antimicrobial photodynamic therapy has considerable promise in the fight against bacterial infections. The superior photophysical characteristics of porphyrins have made them effective photosensitizers in the field of phototherapy. Herein, the light-induced antimicrobial effects of three porphyrins with different substituents have been compared. 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (THPP) shows superior photosensitizing activity and antimicrobial ability under irradiation with green light. THPP can also inhibit and destroy mature Staphylococcus aureus biofilms under irradiation. This work provides a reference for the rational design of photosensitizers for application in antimicrobial photodynamic therapy.