Studying the Efficacy of Vazonat in Comprehensive Treatment of Patients with Diabetes Mellitus Type 2

Abstract

The objective — to study the effectiveness of Vazonat (meldonium) in patients with diabetes mellitus (DM) type 2 in the comparative 12-week study. Materials and methods. The study involved 55 patients with DM type 2. Patients of the first group in addition to the basic treatment for DM received meldonium (Vazonat, OlainFarm JSC, Latvia) at a dose of 1000 mg/day during 12 weeks. The second group included 25 patients with DM type 2 (8 men and 17 women, average age 60.4 ± 1.9 years), who received only basic therapy of DM. Results. 12-week meldonium therapy as a part of combination therapy for DM type 2 statistically significantly improves the performance of kidney function, as indicated by a significant reduction in the level of microalbuminuria, creatinine and increased glomerular filtration rate in the first group of patients. Inclusion in the treatment regimen of Vazonat in patients with type 2 DM improves morphofunctional parameters of the heart, has additional nephroprotective action, reduces the average values of triglycerides and low-density lipoproteins, as well as glycated hemoglobin levels compared to baseline therapy. Conclusions. Vazonat, combining cardioprotective properties and hypoglycemic effect, is a particularly good choice for comprehensive treatment of patients with impaired glucose metabolism, diabetic nephropathy and heart failure.

Keywords

• diabetes mellitus type 2
• сardiorenal risk factors
• meldonium