Topical antifungals in treatment of superficial cutaneous mycoses

Abstract

Superficial cutaneous mycoses are a challenge for practical healthcare all over the world. Considering high incidence of cutaneous mycoses, it is obvious that there is a need to monitor the efficacy and safety of topical antifungals confirmed in the large-scale clinical trials. Today, drugs of two classes, allylamines and azoles, are considered to be the most effective antifungals for treatment of cutaneous mycoses. The review provides the analysis of the results of large-scale clinical trials and meta-analyses aimed to determine the role of modern topical antifungals in treatment of cutaneous mycoses. The options for optimization of the cutaneous mycosis treatment are exemplified by naftifine as a founder of the class of allylamines possessing not only antifungal, but also antibacterial and anti-inflammatory activity.

Keywords

• cutaneous mycoses
• dermatophytosis
• onychomycosis
• antifungal drugs
• antifungals
• naftifine