Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation

Zhaoyun Ding; Ting Cai; Jupei Tang; Hanxiao Sun; Xinyi Qi; Yunpeng Zhang; Yan Ji; Liyun Yuan; Huidan Chang; Yanhui Ma; Hong Zhou; Li Li; Huiming Sheng; Ju Qiu

doi:10.1038/s41467-022-35250-0

Nature Communications (Dec 2022)

Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation

Zhaoyun Ding,
Ting Cai,
Jupei Tang,
Hanxiao Sun,
Xinyi Qi,
Yunpeng Zhang,
Yan Ji,
Liyun Yuan,
Huidan Chang,
Yanhui Ma,
Hong Zhou,
Li Li,
Huiming Sheng,
Ju Qiu

Affiliations

Zhaoyun Ding: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Ting Cai: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jupei Tang: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Hanxiao Sun: Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Xinyi Qi: Shanghai Jiao Tong University School of Medicine (SJTUSM)
Yunpeng Zhang: Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Yan Ji: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Liyun Yuan: CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science
Huidan Chang: CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science
Yanhui Ma: Department of Laboratory Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
Hong Zhou: School of Life Science, Anhui Medical University
Li Li: State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University
Huiming Sheng: Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Ju Qiu: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-35250-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Treg cells can be functionally altered by epigenetic modulators. Here the authors show that the histone H3K36 methyltransferase Setd2 is important for the survival of Treg cells and for the regulation of IL-33 mediated Th2 responses in mice and SETD2 expression is increased in Treg cells from human colorectal cancer tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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