Nature Communications (Sep 2021)
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation
- Kai P. Hoefig,
- Alexander Reim,
- Christian Gallus,
- Elaine H. Wong,
- Gesine Behrens,
- Christine Conrad,
- Meng Xu,
- Lisa Kifinger,
- Taku Ito-Kureha,
- Kyra A. Y. Defourny,
- Arie Geerlof,
- Josef Mautner,
- Stefanie M. Hauck,
- Dirk Baumjohann,
- Regina Feederle,
- Matthias Mann,
- Michael Wierer,
- Elke Glasmacher,
- Vigo Heissmeyer
Affiliations
- Kai P. Hoefig
- Research Unit Molecular Immune Regulation, Helmholtz Center Munich
- Alexander Reim
- Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry
- Christian Gallus
- Institute of Diabetes and Obesity, Helmholtz Center Munich
- Elaine H. Wong
- Institute for Immunology, Biomedical Center, Ludwig Maximilians University Munich
- Gesine Behrens
- Research Unit Molecular Immune Regulation, Helmholtz Center Munich
- Christine Conrad
- Institute for Immunology, Biomedical Center, Ludwig Maximilians University Munich
- Meng Xu
- Research Unit Molecular Immune Regulation, Helmholtz Center Munich
- Lisa Kifinger
- Institute for Immunology, Biomedical Center, Ludwig Maximilians University Munich
- Taku Ito-Kureha
- Institute for Immunology, Biomedical Center, Ludwig Maximilians University Munich
- Kyra A. Y. Defourny
- Institute for Immunology, Biomedical Center, Ludwig Maximilians University Munich
- Arie Geerlof
- Institute of Structural Biology, Helmholtz Center Munich
- Josef Mautner
- Research Unit Gene Vectors, Helmholtz Center Munich & Children’s Hospital, TU Munich
- Stefanie M. Hauck
- Research Unit Protein Science, Helmholtz Center Munich
- Dirk Baumjohann
- Institute for Immunology, Biomedical Center, Ludwig Maximilians University Munich
- Regina Feederle
- Monoclonal Antibody Core Facility and Research Group, Institute for Diabetes and Obesity, Helmholtz Center Munich
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry
- Michael Wierer
- Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry
- Elke Glasmacher
- Institute of Diabetes and Obesity, Helmholtz Center Munich
- Vigo Heissmeyer
- Research Unit Molecular Immune Regulation, Helmholtz Center Munich
- DOI
- https://doi.org/10.1038/s41467-021-25345-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
An extensive RNA binding protein atlas (RBPome) for primary T cells would be a useful resource. Here the authors use two different methods to characterise the mouse and human T cell RBPome and show regulation of Roquin-1/2 dependent and independent pathways.
