Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

F. T. Sparks; Z. Liao; W. Li; A. Grosmark; I. Soltesz; A. Losonczy

doi:10.1038/s41467-020-19969-2

Nature Communications (Dec 2020)

Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

F. T. Sparks,
Z. Liao,
W. Li,
A. Grosmark,
I. Soltesz,
A. Losonczy

Affiliations

F. T. Sparks: Department of Neuroscience, Columbia University
Z. Liao: Department of Neuroscience, Columbia University
W. Li: Department of Neuroscience, Columbia University
A. Grosmark: Department of Neuroscience, Columbia University
I. Soltesz: Department of Neurosurgery, Stanford University
A. Losonczy: Department of Neuroscience, Columbia University

DOI: https://doi.org/10.1038/s41467-020-19969-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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The dentate gyrus is involved in synchronous discharges and seizures, but its microcircuit functional organization in TLE is unclear. Here, the authors show that interictal discharges recruit specific granule cell ensembles dominated by adult-born immature neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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