Nature Communications (Jul 2021)
The molecular basis for SARS-CoV-2 binding to dog ACE2
- Zengyuan Zhang,
- Yanfang Zhang,
- Kefang Liu,
- Yan Li,
- Qiong Lu,
- Qingling Wang,
- Yuqin Zhang,
- Liang Wang,
- Hanyi Liao,
- Anqi Zheng,
- Sufang Ma,
- Zheng Fan,
- Huifang Li,
- Weijin Huang,
- Yuhai Bi,
- Xin Zhao,
- Qihui Wang,
- George F. Gao,
- Haixia Xiao,
- Zhou Tong,
- Jianxun Qi,
- Yeping Sun
Affiliations
- Zengyuan Zhang
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Yanfang Zhang
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Kefang Liu
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Yan Li
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Qiong Lu
- Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC)
- Qingling Wang
- Shanxi Natural Carbohydrate Resource Engineering Research Center, College of Food Science and Technology, Northwest University
- Yuqin Zhang
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Liang Wang
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Hanyi Liao
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Anqi Zheng
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Sufang Ma
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Zheng Fan
- Institute of Microbiology, Chinese Academy of Sciences
- Huifang Li
- The Northern Medical District of the PLA General Hospital
- Weijin Huang
- Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC)
- Yuhai Bi
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Xin Zhao
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Qihui Wang
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- George F. Gao
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Haixia Xiao
- Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
- Zhou Tong
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Jianxun Qi
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Yeping Sun
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-021-24326-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angiotensin-converting enzyme 2 (dACE2), and show that the RBD N501Y mutation increases the infectivity and host range of SARS-CoV-2, which highlights the need to monitor emerging SARS-CoV-2 mutations in domestic animals.
