Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

Jayna J. Mistry; Charlotte Hellmich; Jamie A. Moore; Aisha Jibril; Iain Macaulay; Mar Moreno-Gonzalez; Federica Di Palma; Naiara Beraza; Kristian M. Bowles; Stuart A. Rushworth

doi:10.1038/s41467-021-27460-9

Nature Communications (Dec 2021)

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

Jayna J. Mistry,
Charlotte Hellmich,
Jamie A. Moore,
Aisha Jibril,
Iain Macaulay,
Mar Moreno-Gonzalez,
Federica Di Palma,
Naiara Beraza,
Kristian M. Bowles,
Stuart A. Rushworth

Affiliations

Jayna J. Mistry: Norwich Medical School, University of East Anglia, Norwich Research Park
Charlotte Hellmich: Norwich Medical School, University of East Anglia, Norwich Research Park
Jamie A. Moore: Norwich Medical School, University of East Anglia, Norwich Research Park
Aisha Jibril: Norwich Medical School, University of East Anglia, Norwich Research Park
Iain Macaulay: Earlham Institute, Norwich Research Park
Mar Moreno-Gonzalez: Gut Microbes and Health Institute Strategic Programme, Quadram Institute
Federica Di Palma: Norwich Medical School, University of East Anglia, Norwich Research Park
Naiara Beraza: Gut Microbes and Health Institute Strategic Programme, Quadram Institute
Kristian M. Bowles: Norwich Medical School, University of East Anglia, Norwich Research Park
Stuart A. Rushworth: Norwich Medical School, University of East Anglia, Norwich Research Park

DOI: https://doi.org/10.1038/s41467-021-27460-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Hematopoietic stem cells (HSCs) rapidly expand upon infection, switching their metabolic profile to increase OXPHOS. Here, the authors show in mouse models that infection promotes uptake of long-chain free fatty acids via CD36, which is required for a protective response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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