Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

Dennis W. Zhou; Marc A. Fernández-Yagüe; Elijah N. Holland; Andrés F. García; Nicolas S. Castro; Eric B. O’Neill; Jeroen Eyckmans; Christopher S. Chen; Jianping Fu; David D. Schlaepfer; Andrés J. García

doi:10.1038/s41467-021-22602-5

Nature Communications (Apr 2021)

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

Dennis W. Zhou,
Marc A. Fernández-Yagüe,
Elijah N. Holland,
Andrés F. García,
Nicolas S. Castro,
Eric B. O’Neill,
Jeroen Eyckmans,
Christopher S. Chen,
Jianping Fu,
David D. Schlaepfer,
Andrés J. García

Affiliations

Dennis W. Zhou: Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Marc A. Fernández-Yagüe: Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Elijah N. Holland: Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Andrés F. García: Woodruff School of Mechanical Engineering, Georgia Institute of Technology
Nicolas S. Castro: Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Eric B. O’Neill: Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Jeroen Eyckmans: Department of Biomedical Engineering, Boston University
Christopher S. Chen: Department of Biomedical Engineering, Boston University
Jianping Fu: Department of Mechanical Engineering, Department of Biomedical Engineering, Department of Cell and Developmental Biology, University of Michigan
David D. Schlaepfer: Moores Cancer Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego
Andrés J. García: Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology

DOI: https://doi.org/10.1038/s41467-021-22602-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal