Nature Communications (Mar 2016)
The Gq signalling pathway inhibits brown and beige adipose tissue
- Katarina Klepac,
- Ana Kilić,
- Thorsten Gnad,
- Loren M. Brown,
- Beate Herrmann,
- Andrea Wilderman,
- Aileen Balkow,
- Anja Glöde,
- Katharina Simon,
- Martin E. Lidell,
- Matthias J. Betz,
- Sven Enerbäck,
- Jürgen Wess,
- Marc Freichel,
- Matthias Blüher,
- Gabi König,
- Evi Kostenis,
- Paul A. Insel,
- Alexander Pfeifer
Affiliations
- Katarina Klepac
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Ana Kilić
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Thorsten Gnad
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Loren M. Brown
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Beate Herrmann
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Andrea Wilderman
- Department of Pharmacology, University of California
- Aileen Balkow
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Anja Glöde
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- Katharina Simon
- Research Training Group 1873, University of Bonn
- Martin E. Lidell
- Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg
- Matthias J. Betz
- Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg
- Sven Enerbäck
- Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg
- Jürgen Wess
- Molecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Marc Freichel
- Institute of Pharmacology, University of Heidelberg
- Matthias Blüher
- Department of Medicine, University of Leipzig
- Gabi König
- Institute of Pharmaceutical Biology, University of Bonn
- Evi Kostenis
- Research Training Group 1873, University of Bonn
- Paul A. Insel
- Department of Pharmacology, University of California
- Alexander Pfeifer
- Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn
- DOI
- https://doi.org/10.1038/ncomms10895
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.
