Nature Communications (Nov 2021)
Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
- Naser Ansari-Pour,
- Yonglan Zheng,
- Toshio F. Yoshimatsu,
- Ayodele Sanni,
- Mustapha Ajani,
- Jean-Baptiste Reynier,
- Avraam Tapinos,
- Jason J. Pitt,
- Stefan Dentro,
- Anna Woodard,
- Padma Sheila Rajagopal,
- Dominic Fitzgerald,
- Andreas J. Gruber,
- Abayomi Odetunde,
- Abiodun Popoola,
- Adeyinka G. Falusi,
- Chinedum Peace Babalola,
- Temidayo Ogundiran,
- Nasiru Ibrahim,
- Jordi Barretina,
- Peter Van Loo,
- Mengjie Chen,
- Kevin P. White,
- Oladosu Ojengbede,
- John Obafunwa,
- Dezheng Huo,
- David C. Wedge,
- Olufunmilayo I. Olopade
Affiliations
- Naser Ansari-Pour
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Yonglan Zheng
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago
- Toshio F. Yoshimatsu
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago
- Ayodele Sanni
- Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital, Ikeja
- Mustapha Ajani
- Department of Pathology, University of Ibadan
- Jean-Baptiste Reynier
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago
- Avraam Tapinos
- Manchester Cancer Research Centre, University of Manchester
- Jason J. Pitt
- Cancer Science Institute of Singapore, National University of Singapore
- Stefan Dentro
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Anna Woodard
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago
- Padma Sheila Rajagopal
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago
- Dominic Fitzgerald
- Institute for Genomics and Systems Biology, University of Chicago
- Andreas J. Gruber
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Abayomi Odetunde
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Abiodun Popoola
- Oncology Unit, Department of Radiology, Lagos State University, Ikeja
- Adeyinka G. Falusi
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Chinedum Peace Babalola
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan
- Temidayo Ogundiran
- Department of Surgery, University College Hospital
- Nasiru Ibrahim
- Department of Surgery, Lagos State University Teaching Hospital
- Jordi Barretina
- Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta
- Peter Van Loo
- The Francis Crick Institute
- Mengjie Chen
- Department of Human Genetics, The University of Chicago
- Kevin P. White
- Tempus Labs Inc.
- Oladosu Ojengbede
- Centre for Population and Reproductive Health, College of Medicine, University of Ibadan
- John Obafunwa
- Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital, Ikeja
- Dezheng Huo
- Department of Public Health Sciences, The University of Chicago
- David C. Wedge
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Olufunmilayo I. Olopade
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago
- DOI
- https://doi.org/10.1038/s41467-021-27079-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Breast cancer heterogeneity and tumour evolutionary trajectories remain largely unknown among women of African ancestry. Here, the authors perform whole genome and transcriptome sequencing of Nigerian breast cancer patients and identify unique evolutionary phenomena.
