Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis

Kentaro Yamamoto; Noboru Nakata; Tetsu Mukai; Ikuro Kawagishi; Manabu Ato

doi:10.1128/mSphere.00518-20

mSphere (Feb 2021)

Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis

Kentaro Yamamoto,
Noboru Nakata,
Tetsu Mukai,
Ikuro Kawagishi,
Manabu Ato

Affiliations

Kentaro Yamamoto: ORCiD; Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Noboru Nakata: Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Tetsu Mukai: Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Ikuro Kawagishi: Department of Frontier Bioscience, Hosei University, Koganei, Tokyo, Japan
Manabu Ato: ORCiD; Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan

DOI: https://doi.org/10.1128/mSphere.00518-20
Journal volume & issue: Vol. 6, no. 1

Abstract

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It has been reported that mycobacterial membrane protein large 5 (MmpL5), a resistance-nodulation-division (RND)-type inner membrane transporter in Mycobacterium tuberculosisMtb

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

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