Nature Communications (Mar 2021)
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer
- Emily Golden,
- Rabab Rashwan,
- Eleanor A. Woodward,
- Agustin Sgro,
- Edina Wang,
- Anabel Sorolla,
- Charlene Waryah,
- Wan Jun Tie,
- Elisabet Cuyàs,
- Magdalena Ratajska,
- Iwona Kardaś,
- Piotr Kozlowski,
- Elizabeth K. M. Johnstone,
- Heng B. See,
- Ciara Duffy,
- Jeremy Parry,
- Kim A. Lagerborg,
- Piotr Czapiewski,
- Javier A. Menendez,
- Adam Gorczyński,
- Bartosz Wasag,
- Kevin D. G. Pfleger,
- Christina Curtis,
- Bum-Kyu Lee,
- Jonghwan Kim,
- Joseph Cursons,
- Nathan J. Pavlos,
- Wojciech Biernat,
- Mohit Jain,
- Andrew J. Woo,
- Andrew Redfern,
- Pilar Blancafort
Affiliations
- Emily Golden
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Rabab Rashwan
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Eleanor A. Woodward
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Agustin Sgro
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Edina Wang
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Anabel Sorolla
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Charlene Waryah
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Wan Jun Tie
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Elisabet Cuyàs
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Magdalena Ratajska
- Department of Biology and Medical Genetics, Medical University of Gdansk
- Iwona Kardaś
- Department of Biology and Medical Genetics, Medical University of Gdansk
- Piotr Kozlowski
- Institute of Bioorganic Chemistry, Polish Academy of Sciences
- Elizabeth K. M. Johnstone
- Centre for Medical Research, The University of Western Australia
- Heng B. See
- Centre for Medical Research, The University of Western Australia
- Ciara Duffy
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- Jeremy Parry
- Department of Anatomical Pathology, Path West Laboratory, Fiona Stanley Hospital Network
- Kim A. Lagerborg
- Departments of Medicine and Pharmacology, University of California
- Piotr Czapiewski
- Department of Pathomorphology, Medical University of Gdansk
- Javier A. Menendez
- Girona Biomedical Research Institute
- Adam Gorczyński
- Department of Pathomorphology, Medical University of Gdansk
- Bartosz Wasag
- Department of Biology and Medical Genetics, Medical University of Gdansk
- Kevin D. G. Pfleger
- Centre for Medical Research, The University of Western Australia
- Christina Curtis
- Stanford University School of Medicine (Departments of Medicine & Genetics) and Stanford Cancer Institute
- Bum-Kyu Lee
- Department of Biomedical Sciences, Cancer Research Center, University at Albany-State University of New York
- Jonghwan Kim
- Department of Molecular Biosciences, Center for Systems and Synthetic Biology, The University of Texas at Austin
- Joseph Cursons
- Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University
- Nathan J. Pavlos
- The Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia
- Wojciech Biernat
- Department of Pathomorphology, Medical University of Gdansk
- Mohit Jain
- Departments of Medicine and Pharmacology, University of California
- Andrew J. Woo
- Centre for Medical Research, The University of Western Australia
- Andrew Redfern
- School of Medicine, University of Western Australia
- Pilar Blancafort
- Cancer Epigenetics Group, The Harry Perkins Institute of Medical Research, The University of Western Australia
- DOI
- https://doi.org/10.1038/s41467-021-22101-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.
