Nature Communications (Feb 2023)
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
- Konxhe Kulaj,
- Alexandra Harger,
- Michaela Bauer,
- Özüm S. Caliskan,
- Tilak Kumar Gupta,
- Dapi Menglin Chiang,
- Edward Milbank,
- Josefine Reber,
- Angelos Karlas,
- Petra Kotzbeck,
- David N. Sailer,
- Francesco Volta,
- Dominik Lutter,
- Sneha Prakash,
- Juliane Merl-Pham,
- Vasilis Ntziachristos,
- Hans Hauner,
- Michael W. Pfaffl,
- Matthias H. Tschöp,
- Timo D. Müller,
- Stefanie M. Hauck,
- Benjamin D. Engel,
- Jantje M. Gerdes,
- Paul T. Pfluger,
- Natalie Krahmer,
- Kerstin Stemmer
Affiliations
- Konxhe Kulaj
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Alexandra Harger
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Michaela Bauer
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Özüm S. Caliskan
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Tilak Kumar Gupta
- Department of Molecular Structural Biology, Max Planck Institute of Biochemistry
- Dapi Menglin Chiang
- Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich
- Edward Milbank
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Josefine Reber
- Institute of Biological and Medical Imaging, Helmholtz Zentrum München
- Angelos Karlas
- Institute of Biological and Medical Imaging, Helmholtz Zentrum München
- Petra Kotzbeck
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- David N. Sailer
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Francesco Volta
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Dominik Lutter
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Sneha Prakash
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Juliane Merl-Pham
- Metabolomics and Proteomics Core, Helmholtz Zentrum München
- Vasilis Ntziachristos
- Institute of Biological and Medical Imaging, Helmholtz Zentrum München
- Hans Hauner
- Institute for Nutritional Medicine, School of Medicine, Technical University of Munich
- Michael W. Pfaffl
- Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich
- Matthias H. Tschöp
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Timo D. Müller
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Stefanie M. Hauck
- Metabolomics and Proteomics Core, Helmholtz Zentrum München
- Benjamin D. Engel
- Helmholtz Pioneer Campus, Helmholtz Zentrum München
- Jantje M. Gerdes
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Paul T. Pfluger
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Natalie Krahmer
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Kerstin Stemmer
- Institute for Diabetes and Obesity, Helmholtz Zentrum München
- DOI
- https://doi.org/10.1038/s41467-023-36148-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfer of insulinotropic proteins from adipose tissue to β-cells.
