Nature Communications (May 2017)

Joint morphogenetic cells in the adult mammalian synovium

  • Anke J. Roelofs,
  • Janja Zupan,
  • Anna H. K. Riemen,
  • Karolina Kania,
  • Sharon Ansboro,
  • Nathan White,
  • Susan M. Clark,
  • Cosimo De Bari

DOI
https://doi.org/10.1038/ncomms15040
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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The stem cells that maintain and repair adult joint tissues in mammals, including articular cartilage, remain incompletely defined. Here the authors perform lineage tracing studies in adult mice and find an ontogenetically defined progenitor cell population that is functional in the synovial joint and distinct from previously reported mesenchymal stem cell populations.