Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Neil Justin; Ying Zhang; Cataldo Tarricone; Stephen R. Martin; Shuyang Chen; Elizabeth Underwood; Valeria De Marco; Lesley F. Haire; Philip A. Walker; Danny Reinberg; Jon R. Wilson; Steven J. Gamblin

doi:10.1038/ncomms11316

Nature Communications (Apr 2016)

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Neil Justin,
Ying Zhang,
Cataldo Tarricone,
Stephen R. Martin,
Shuyang Chen,
Elizabeth Underwood,
Valeria De Marco,
Lesley F. Haire,
Philip A. Walker,
Danny Reinberg,
Jon R. Wilson,
Steven J. Gamblin

Affiliations

Neil Justin: The Francis Crick Institute, Mill Hill Laboratory
Ying Zhang: The Francis Crick Institute, Mill Hill Laboratory
Cataldo Tarricone: The Francis Crick Institute, Mill Hill Laboratory
Stephen R. Martin: Structural Biology Science Technology Platform, Francis Crick Institute, Mill Hill Laboratory
Shuyang Chen: The Francis Crick Institute, Mill Hill Laboratory
Elizabeth Underwood: The Francis Crick Institute, Mill Hill Laboratory
Valeria De Marco: The Francis Crick Institute, Mill Hill Laboratory
Lesley F. Haire: The Francis Crick Institute, Mill Hill Laboratory
Philip A. Walker: Structural Biology Science Technology Platform, Francis Crick Institute, Mill Hill Laboratory
Danny Reinberg: Department of Molecular Pharmacology and Biochemistry, New York University School of Medicine
Jon R. Wilson: The Francis Crick Institute, Mill Hill Laboratory
Steven J. Gamblin: The Francis Crick Institute, Mill Hill Laboratory

DOI: https://doi.org/10.1038/ncomms11316
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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